克罗米酚对男性低促性腺素高血压减退症有效

纽约（消息来源肥胖版）1月末四日报道：据发表在12月末出版的《生育与不育》杂志的一项科学研究报告指出克罗米醇对部分偏高促连续性腺伦精神分裂症有增无减的年长者患儿利于。来自谢菲尔德新罕布什尔大学的该科学研究报告的第一著者Scott J. Whitten博士在接受路透通讯社专访时话说：“病变或获得连续性HH患儿在接受侵害连续性更大和极其昂贵的治疗（例如注射促连续性腺激伦类）前展开4个月末的克罗米醇试验连续性治疗是利于的。”Whitten博士和同事科学研究了克罗米醇对10名HH年长者患儿（HH是导致年长者不育的少见因伦）前提适当。科学研究报告称克罗米醇治疗1年后，4名康拉德(氏)综合征患儿中只有一名患儿的乳腺溶解度增加而全垂体机制有增无减症患儿的乳腺缺乏症状均无法受益改善。同样，该科学研究报告指出3名成年发病的病变HH年长者患儿经过3个月末克罗米醇的治疗乳腺溶解度有了明显增加。目前为止该组患儿已有两名恢复了生育能力。Whitten博士话说：“除非对克罗米醇治疗无法反应，我们不会因为副作用暂缓对患儿使用该药物。”最终著者揭示话说：“因为条件极少，对HH患儿促连续性腺激伦镇静剂和克罗米醇的随机科学研究难以展开，然而借助于多系列的严格选择标准对患儿展开分级可能为了让进一步验证克罗米醇恢复年长者偏高生育能力的适当连续性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖